Buclizine Hydrochloride
The hydrochloride salt of buclizine, used to prevent and treat motion sickness, vertigo, and nausea. Its central antihistamine and anticholinergic activity helps suppress signals that trigger the vomiting reflex. It has sedative effects that may also contribute to its antiemetic action.
Berat Molekul
505,9000 g/mol
TPSA
6,50 Ų
Mekanisme Kerja
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Struktur 2D
Cite this structure
Embed this structure
SMILES
CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1.Cl.Cl
InChI
InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H
Molecular Formula
C28H35Cl3N2
HBD / HBA
2 / 2
Ikatan yang Dapat Dirotasi
6
Atom Berat
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
The hydrochloride salt of buclizine, used to prevent and treat motion sickness, vertigo, and nausea. Its central antihistamine and anticholinergic activity helps suppress signals that trigger the vomiting reflex. It has sedative effects that may also contribute to its antiemetic action.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Buclizine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2360580. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 65463. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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