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Butoconazole

CHEMBL1295 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
411.8 g/mol
LogP
6.4
Phase
4

An azole antifungal used as a vaginal cream to treat vaginal yeast infections caused by Candida species. It works by inhibiting ergosterol synthesis, disrupting the fungal cell membrane. A single-dose formulation provides convenience for treatment of uncomplicated vaginal candidiasis.

Berat Molekul

411,8000 g/mol

LogP

6,40

TPSA

43,10 Ų

Lipinski RO5

Lulus

Mekanisme Kerja

Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

Struktur 2D

SVG PNG

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SMILES

                    
Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C19H17Cl3N2S/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22/h1-5,7-8,10-11,13,16H,6,9,12H2

                

                

                

                    
                    

                        
Molecular Formula

                        
C19H17Cl3N2S

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
7

                    

                    
                    
                    

                        
Atom Berat

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
An azole antifungal used as a vaginal cream to treat vaginal yeast infections caused by Candida species. It works by inhibiting ergosterol synthesis, disrupting the fungal cell membrane. A single-dose formulation provides convenience for treatment of uncomplicated vaginal candidiasis.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Butoconazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1295.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 47472.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.