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Cefotaxime

CHEMBL1730 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
455.5 g/mol
LogP
-1.4
Phase
4

A third-generation cephalosporin antibiotic with broad-spectrum activity against gram-negative bacteria and many gram-positive organisms, widely used for meningitis, sepsis, and serious respiratory and urinary tract infections. It penetrates the blood-brain barrier effectively, making it valuable in central nervous system infections. It is metabolized to desacetylcefotaxime, which retains some antibacterial activity.

Berat Molekul

455,5000 g/mol

LogP

-1,40

TPSA

227,00 Ų

Lipinski RO5

Lulus

Area Terapeutik

Pancreatic Cancer Cardiovascular Disease Chronic Obstructive Pulmonary Disease Parkinson's Disease Schizophrenia Bipolar Disorder Infectious Disease Gastroesophageal Reflux Disease Inflammatory Bowel Disease Chronic Kidney Disease Stroke Colorectal Cancer

Mekanisme Kerja

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(COC(C)=O)CS[C@H]12)c1csc(N)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H17N5O7S2

                    

                    
                    

                        
HBD / HBA

                        
3 / 12

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
8

                    

                    
                    
                    

                        
Atom Berat

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
A third-generation cephalosporin antibiotic with broad-spectrum activity against gram-negative bacteria and many gram-positive organisms, widely used for meningitis, sepsis, and serious respiratory and urinary tract infections. It penetrates the blood-brain barrier effectively, making it valuable in central nervous system infections. It is metabolized to desacetylcefotaxime, which retains some antibacterial activity.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Cefotaxime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1730.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5742673.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.