Dexbrompheniramine
The dextrorotatory stereoisomer of brompheniramine, a first-generation antihistamine used to relieve allergy symptoms including runny nose, sneezing, and itching. It is more potent than the racemic mixture and causes sedation.
Berat Molekul
319,2400 g/mol
LogP
3,50
TPSA
16,10 Ų
Lipinski RO5
Lulus
Mekanisme Kerja
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Struktur 2D
Cite this structure
Embed this structure
SMILES
CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
Molecular Formula
C16H19BrN2
HBD / HBA
- / 2
Ikatan yang Dapat Dirotasi
5
Atom Berat
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
The dextrorotatory stereoisomer of brompheniramine, a first-generation antihistamine used to relieve allergy symptoms including runny nose, sneezing, and itching. It is more potent than the racemic mixture and causes sedation.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Dexbrompheniramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201287. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 16960. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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