Dihydrostreptomycin
An aminoglycoside antibiotic closely related to streptomycin, used to treat bacterial infections including tuberculosis. It works by interfering with bacterial protein synthesis to kill or stop the growth of bacteria.
Berat Molekul
583,6000 g/mol
LogP
-8,20
TPSA
340,00 Ų
Lipinski RO5
Gagal
Mekanisme Kerja
Binds irreversibly to the 30S ribosomal subunit, causing misreading of mRNA codons and inhibition of translocation. This leads to production of aberrant proteins and disruption of the bacterial cell membrane.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds irreversibly to the 30S ribosomal subunit, causing misreading of mRNA codons and inhibition of translocation. This leads to production of aberrant proteins and disruption of the bacterial cell membrane.
Struktur 2D
Cite this structure
Embed this structure
SMILES
CN[C@@H]1[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)CO)O[C@@H](CO)[C@H](O)[C@H]1O
InChI
InChI=1S/C21H41N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1
Molecular Formula
C21H41N7O12
HBD / HBA
13 / 15
Ikatan yang Dapat Dirotasi
9
Atom Berat
40
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
An aminoglycoside antibiotic closely related to streptomycin, used to treat bacterial infections including tuberculosis. It works by interfering with bacterial protein synthesis to kill or stop the growth of bacteria.
Binds irreversibly to the 30S ribosomal subunit, causing misreading of mRNA codons and inhibition of translocation. This leads to production of aberrant proteins and disruption of the bacterial cell membrane.
Yes, Dihydrostreptomycin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1950576. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 439369. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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