Dofetilide

CHEMBL473 Phase 4 Disetujui Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

441.6 g/mol

LogP

1.8

Phase

4

A class III antiarrhythmic drug used to convert atrial fibrillation and flutter to normal sinus rhythm and to maintain normal rhythm after conversion. It works by blocking potassium channels in the heart, prolonging the action potential. It can cause a potentially dangerous prolongation of the QT interval leading to life-threatening arrhythmias, so initiation must occur in hospital with continuous cardiac monitoring.

Berat Molekul

441,6000 g/mol

LogP

1,80

TPSA

122,00 Å²

Lipinski RO5

Lulus

Area Terapeutik

Stroke Heart Failure Atrial Fibrillation

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

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SMILES

CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1

InChI

InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

Molecular Formula

C19H27N3O5S2

HBD / HBA

2 / 8

Ikatan yang Dapat Dirotasi

11

Atom Berat

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Pertanyaan yang Sering Diajukan

A class III antiarrhythmic drug used to convert atrial fibrillation and flutter to normal sinus rhythm and to maintain normal rhythm after conversion. It works by blocking potassium channels in the heart, prolonging the action potential. It can cause a potentially dangerous prolongation of the QT interval leading to life-threatening arrhythmias, so initiation must occur in hospital with continuous cardiac monitoring.

Yes, Dofetilide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL473. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 71329. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Dofetilide di PillFYI

Struktur

Data Cepat

Rumus: C19H27N3O5S2
Sinonim: 1

Tautan Eksternal

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Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.