Fluorouracil
This chemotherapy drug disrupts DNA and RNA synthesis in rapidly dividing cells by mimicking the building blocks that cells need to replicate. It is used to treat various cancers including colorectal, breast, and skin cancers, and topically to treat precancerous skin lesions.
Berat Molekul
130,0800 g/mol
LogP
-0,90
TPSA
58,20 Ų
Lipinski RO5
Lulus
Area Terapeutik
Mekanisme Kerja
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Struktur 2D
Cite this structure
Embed this structure
SMILES
O=c1[nH]cc(F)c(=O)[nH]1
InChI
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
Molecular Formula
C4H3FN2O2
HBD / HBA
2 / 3
Ikatan yang Dapat Dirotasi
0
Atom Berat
9
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
This chemotherapy drug disrupts DNA and RNA synthesis in rapidly dividing cells by mimicking the building blocks that cells need to replicate. It is used to treat various cancers including colorectal, breast, and skin cancers, and topically to treat precancerous skin lesions.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Fluorouracil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL185. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3385. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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