Fostemsavir
This antiretroviral prodrug is converted to temsavir, which blocks HIV entry into human cells by binding directly to the viral gp120 protein and preventing it from attaching to the CD4 receptor. It is used in heavily treatment-experienced adults with multidrug-resistant HIV.
Berat Molekul
583,5000 g/mol
LogP
-0,10
TPSA
182,00 Ų
Lipinski RO5
Gagal
Mekanisme Kerja
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Struktur 2D
Cite this structure
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SMILES
COc1cnc(-n2cnc(C)n2)c2c1c(C(=O)C(=O)N1CCN(C(=O)c3ccccc3)CC1)cn2COP(=O)(O)O
InChI
InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38)
Molecular Formula
C25H26N7O8P
HBD / HBA
2 / 11
Ikatan yang Dapat Dirotasi
8
Atom Berat
41
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
This antiretroviral prodrug is converted to temsavir, which blocks HIV entry into human cells by binding directly to the viral gp120 protein and preventing it from attaching to the CD4 receptor. It is used in heavily treatment-experienced adults with multidrug-resistant HIV.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Fostemsavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3301594. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11319217. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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