Halofantrine Hydrochloride

CHEMBL1200901 Phase 4 Disetujui Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

536.9 g/mol

LogP

—

Phase

4

A hydrochloride salt form of halofantrine, an antimalarial agent used against chloroquine-resistant malaria strains, particularly in regions where drug resistance is prevalent. The hydrochloride form is the commercially used oral preparation. Due to significant cardiac risks including fatal arrhythmias, its use requires careful patient selection and cardiac monitoring.

Berat Molekul

536,9000 g/mol

TPSA

23,50 Å²

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Glaucoma Cardiovascular Disease Pain Management Non-Small Cell Lung Cancer Schizophrenia Generalized Anxiety Disorder Systemic Lupus Erythematosus Obesity Transplant Medicine Hypertension Major Depressive Disorder Breast Cancer Malaria HIV/AIDS Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

SVG PNG

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SMILES

CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c2cc(C(F)(F)F)ccc12.Cl

InChI

InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H

Molecular Formula

C26H31Cl3F3NO

HBD / HBA

2 / 5

Ikatan yang Dapat Dirotasi

10

Atom Berat

34

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Pertanyaan yang Sering Diajukan

A hydrochloride salt form of halofantrine, an antimalarial agent used against chloroquine-resistant malaria strains, particularly in regions where drug resistance is prevalent. The hydrochloride form is the commercially used oral preparation. Due to significant cardiac risks including fatal arrhythmias, its use requires careful patient selection and cardiac monitoring.

Yes, Halofantrine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200901. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 37392. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Struktur

Data Cepat

Rumus: C26H31Cl3F3NO

Tautan Eksternal

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Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.