Indapamide
This thiazide-like diuretic is used to treat high blood pressure and fluid retention (edema) associated with heart failure. It reduces blood pressure by promoting sodium and water excretion in the kidneys, decreasing blood volume, and also by directly relaxing blood vessels. It is often preferred for hypertension due to its neutral effect on blood lipids and glucose.
Berat Molekul
365,8000 g/mol
LogP
2,90
TPSA
101,00 Ų
Lipinski RO5
Lulus
Area Terapeutik
Mekanisme Kerja
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Struktur 2D
Cite this structure
Embed this structure
SMILES
CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(S(N)(=O)=O)c1
InChI
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
Molecular Formula
C16H16ClN3O3S
HBD / HBA
2 / 5
Ikatan yang Dapat Dirotasi
3
Atom Berat
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
This thiazide-like diuretic is used to treat high blood pressure and fluid retention (edema) associated with heart failure. It reduces blood pressure by promoting sodium and water excretion in the kidneys, decreasing blood volume, and also by directly relaxing blood vessels. It is often preferred for hypertension due to its neutral effect on blood lipids and glucose.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Indapamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL406. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3702. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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