Isoxicam
This NSAID was withdrawn from the market shortly after its introduction in the 1980s due to a high rate of serious skin reactions, including potentially life-threatening Stevens-Johnson syndrome. It had been developed to treat arthritis and other inflammatory conditions.
Berat Molekul
335,3400 g/mol
LogP
3,00
TPSA
121,00 Ų
Lipinski RO5
Lulus
Mekanisme Kerja
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Struktur 2D
Cite this structure
Embed this structure
SMILES
Cc1cc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)no1
InChI
InChI=1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)
Molecular Formula
C14H13N3O5S
HBD / HBA
2 / 7
Ikatan yang Dapat Dirotasi
2
Atom Berat
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
This NSAID was withdrawn from the market shortly after its introduction in the 1980s due to a high rate of serious skin reactions, including potentially life-threatening Stevens-Johnson syndrome. It had been developed to treat arthritis and other inflammatory conditions.
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Yes, Isoxicam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL53292. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 54677972. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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