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Phenoxypropazine

CHEMBL1909286 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
166.2 g/mol
LogP
1.1
Phase
4

Phenoxypropazine is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits both MAO-A and MAO-B enzymes, thereby increasing synaptic concentrations of serotonin, norepinephrine, and dopamine. It was investigated as an antidepressant but was largely supplanted by safer antidepressant classes due to its significant food and drug interaction profile.

Berat Molekul

166,2200 g/mol

LogP

1,10

TPSA

47,30 Ų

Lipinski RO5

Lulus

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(COc1ccccc1)NN

                

                

                
                

                    
InChI

                    
InChI=1S/C9H14N2O/c1-8(11-10)7-12-9-5-3-2-4-6-9/h2-6,8,11H,7,10H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H14N2O

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
4

                    

                    
                    
                    

                        
Atom Berat

                        
12

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
Phenoxypropazine is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits both MAO-A and MAO-B enzymes, thereby increasing synaptic concentrations of serotonin, norepinephrine, and dopamine. It was investigated as an antidepressant but was largely supplanted by safer antidepressant classes due to its significant food and drug interaction profile.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Phenoxypropazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1909286.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 71467.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.