Pyrithione
Pyrithione is a metal chelating compound with broad-spectrum antimicrobial activity, most commonly formulated as zinc pyrithione, that disrupts membrane transport systems in fungi and bacteria through formation of inhibitory metal complexes with pyruvate dehydrogenase and other enzymes. It is used as an antifungal and antibacterial agent in dandruff shampoos, antifouling coatings, and has been investigated for various skin conditions.
Berat Molekul
127,1700 g/mol
LogP
0,50
TPSA
55,60 Ų
Lipinski RO5
Lulus
Area Terapeutik
Mekanisme Kerja
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Struktur 2D
Cite this structure
Embed this structure
SMILES
[O-][n+]1ccccc1S
InChI
InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,8H
Molecular Formula
C5H5NOS
HBD / HBA
1 / 2
Ikatan yang Dapat Dirotasi
0
Atom Berat
8
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
Pyrithione is a metal chelating compound with broad-spectrum antimicrobial activity, most commonly formulated as zinc pyrithione, that disrupts membrane transport systems in fungi and bacteria through formation of inhibitory metal complexes with pyruvate dehydrogenase and other enzymes. It is used as an antifungal and antibacterial agent in dandruff shampoos, antifouling coatings, and has been investigated for various skin conditions.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Pyrithione is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1356238. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 1570. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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