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Saralasin

CHEMBL938 Phase 4 Disetujui Protein
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
912.0 g/mol
LogP
-2.6
Phase
4

Saralasin is a synthetic octapeptide angiotensin II receptor antagonist, one of the earliest competitive blockers of the renin-angiotensin system, used historically for the diagnosis of renovascular hypertension and angiotensin-dependent hypertension. As a partial agonist at angiotensin II receptors, it competitively displaces endogenous angiotensin II, transiently lowering blood pressure in renin-dependent hypertension. It has been largely replaced by orally active ARBs and ACE inhibitors in clinical practice.

Berat Molekul

912,0000 g/mol

LogP

-2,60

TPSA

358,00 Ų

Lipinski RO5

Gagal

Mekanisme Kerja

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C42H65N13O10

                    

                    
                    

                        
HBD / HBA

                        
12 / 13

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
25

                    

                    
                    
                    

                        
Atom Berat

                        
65

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
Saralasin is a synthetic octapeptide angiotensin II receptor antagonist, one of the earliest competitive blockers of the renin-angiotensin system, used historically for the diagnosis of renovascular hypertension and angiotensin-dependent hypertension. As a partial agonist at angiotensin II receptors, it competitively displaces endogenous angiotensin II, transiently lowering blood pressure in renin-dependent hypertension. It has been largely replaced by orally active ARBs and ACE inhibitors in clinical practice.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Saralasin is an approved drug. It has reached clinical phase 4. It is classified as a Protein.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL938.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6324663.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.