Sonidegib

CHEMBL2105737 Phase 4 Disetujui Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

485.5 g/mol

LogP

5.8

Phase

4

By blocking the Hedgehog signaling pathway that drives tumor cell growth, this oral targeted therapy is used for advanced or recurrent basal cell carcinoma when surgery or radiation is not appropriate. It is also under investigation for other Hedgehog-driven cancers including certain leukemias.

Berat Molekul

485,5000 g/mol

LogP

5,80

TPSA

63,70 Å²

Lipinski RO5

Lulus

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Non-Small Cell Lung Cancer Melanoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

SVG PNG

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SMILES

Cc1c(C(=O)Nc2ccc(N3C[C@@H](C)O[C@@H](C)C3)nc2)cccc1-c1ccc(OC(F)(F)F)cc1

InChI

InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+

Molecular Formula

C26H26F3N3O3

HBD / HBA

1 / 8

Ikatan yang Dapat Dirotasi

5

Atom Berat

35

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Pertanyaan yang Sering Diajukan

By blocking the Hedgehog signaling pathway that drives tumor cell growth, this oral targeted therapy is used for advanced or recurrent basal cell carcinoma when surgery or radiation is not appropriate. It is also under investigation for other Hedgehog-driven cancers including certain leukemias.

Yes, Sonidegib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105737. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 24775005. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Struktur

Data Cepat

Rumus: C26H26F3N3O3
Sinonim: 1

Tautan Eksternal

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Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.