Tribromsalan

CHEMBL24944 Phase 4 Disetujui Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

449.9 g/mol

LogP

5.0

Phase

4

Tribromsalan (TBS, 3,4,5-tribromosalicylanilide) is a halogenated salicylanilide with antibacterial and antifungal properties that disrupts microbial membrane integrity and inhibits enzyme systems through electrophilic reactivity. It was used as an antimicrobial ingredient in soaps and personal care products but was banned in the United States by the FDA due to photocontact sensitization causing photoallergic contact dermatitis and lack of proven clinical benefit over plain soap. It represents an early antimicrobial triclosan-related agent with unacceptable safety profile.

Berat Molekul

449,9200 g/mol

LogP

5,00

TPSA

49,30 Å²

Lipinski RO5

Lulus

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

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SMILES

O=C(Nc1ccc(Br)cc1)c1cc(Br)cc(Br)c1O

InChI

InChI=1S/C13H8Br3NO2/c14-7-1-3-9(4-2-7)17-13(19)10-5-8(15)6-11(16)12(10)18/h1-6,18H,(H,17,19)

Molecular Formula

C13H8Br3NO2

HBD / HBA

2 / 2

Ikatan yang Dapat Dirotasi

2

Atom Berat

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Pertanyaan yang Sering Diajukan

Tribromsalan (TBS, 3,4,5-tribromosalicylanilide) is a halogenated salicylanilide with antibacterial and antifungal properties that disrupts microbial membrane integrity and inhibits enzyme systems through electrophilic reactivity. It was used as an antimicrobial ingredient in soaps and personal care products but was banned in the United States by the FDA due to photocontact sensitization causing photoallergic contact dermatitis and lack of proven clinical benefit over plain soap. It represents an early antimicrobial triclosan-related agent with unacceptable safety profile.

Yes, Tribromsalan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL24944. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 14868. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Tribromsalan di PillFYI

Struktur

Data Cepat

Rumus: C13H8Br3NO2

Tautan Eksternal

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Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.