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Trimethoprim Hydrochloride

CHEMBL1201080 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
326.8 g/mol
LogP
—
Phase
4

A hydrochloride salt form of trimethoprim with the same therapeutic properties. This antibiotic is used to treat and prevent urinary tract infections and is often combined with sulfamethoxazole (as co-trimoxazole or Bactrim) to treat a broader range of infections including certain types of pneumonia.

Berat Molekul

326,7800 g/mol

TPSA

106,00 Ų

Area Terapeutik

Infectious Disease Bladder Cancer Benign Prostatic Hyperplasia Glaucoma Age-Related Macular Degeneration Hematology Chronic Obstructive Pulmonary Disease Schizophrenia Systemic Lupus Erythematosus Chronic Kidney Disease Stroke Obesity Lymphoma Breast Cancer Atopic Dermatitis Malaria HIV/AIDS Tuberculosis Prostate Cancer Leukemia

Mekanisme Kerja

Dihydrofolate reductase inhibitor (bacterial selective).

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Dihydrofolate reductase inhibitor (bacterial selective).

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C14H18N4O3.ClH/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;/h5-7H,4H2,1-3H3,(H4,15,16,17,18);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H19ClN4O3

                    

                    
                    

                        
HBD / HBA

                        
3 / 7

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
5

                    

                    
                    
                    

                        
Atom Berat

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
A hydrochloride salt form of trimethoprim with the same therapeutic properties. This antibiotic is used to treat and prevent urinary tract infections and is often combined with sulfamethoxazole (as co-trimoxazole or Bactrim) to treat a broader range of infections including certain types of pneumonia.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Dihydrofolate reductase inhibitor (bacterial selective).

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Trimethoprim Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201080.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 173769.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.