Trimetrexate Glucuronate

CHEMBL2218878 Phase 4 Disetujui Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

563.6 g/mol

LogP

—

Phase

4

Trimetrexate glucuronate is the glucuronate salt of trimetrexate, a DHFR inhibitor with antifolate and antiprotozoal activity used in treating Pneumocystis pneumonia in AIDS patients who cannot tolerate standard therapy. It has also been investigated in the treatment of malignancies including colorectal cancer and leukemia due to its cytotoxic mechanism of folate pathway disruption. Leucovorin is co-administered to prevent host toxicity.

Berat Molekul

563,6000 g/mol

TPSA

253,00 Å²

Area Terapeutik

Pancreatic Cancer Lymphoma Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

SVG PNG

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SMILES

COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC.O=C(O)[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

InChI=1S/C19H23N5O3.C6H10O7/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3;7-1-2(8)4(5(10)11)13-6(12)3(1)9/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24);1-4,6-9,12H,(H,10,11)/t;1-,2-,3+,4-,6-/m.0/s1

Molecular Formula

C25H33N5O10

HBD / HBA

8 / 15

Ikatan yang Dapat Dirotasi

11

Atom Berat

40

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Pertanyaan yang Sering Diajukan

Trimetrexate glucuronate is the glucuronate salt of trimetrexate, a DHFR inhibitor with antifolate and antiprotozoal activity used in treating Pneumocystis pneumonia in AIDS patients who cannot tolerate standard therapy. It has also been investigated in the treatment of malignancies including colorectal cancer and leukemia due to its cytotoxic mechanism of folate pathway disruption. Leucovorin is co-administered to prevent host toxicity.

Yes, Trimetrexate Glucuronate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2218878. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 54949. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Struktur

Data Cepat

Rumus: C25H33N5O10

Tautan Eksternal

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Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.