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Vidarabine

CHEMBL1090 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
267.2 g/mol
LogP
-1.1
Phase
4

Vidarabine (adenine arabinoside, Ara-A) is a purine nucleoside analog that is phosphorylated intracellularly to vidarabine triphosphate, which inhibits viral DNA polymerases and DNA primase, blocking viral DNA replication with selectivity for herpes viruses. It was used topically for herpes simplex keratitis and systemically for herpes encephalitis and neonatal herpes, but has largely been replaced by acyclovir due to the latter's improved safety and efficacy profile. Its antiviral mechanism targeting viral DNA polymerase established the template for subsequent nucleoside analog antivirals.

Berat Molekul

267,2400 g/mol

LogP

-1,10

TPSA

140,00 Ų

Lipinski RO5

Lulus

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Respiratory Disease Non-Small Cell Lung Cancer Rheumatoid Arthritis Chronic Obstructive Pulmonary Disease Alzheimer's Disease Parkinson's Disease Infectious Disease Gastroesophageal Reflux Disease Inflammatory Bowel Disease Systemic Lupus Erythematosus Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Mekanisme Kerja

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O

                

                

                
                

                    
InChI

                    
InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H13N5O4

                    

                    
                    

                        
HBD / HBA

                        
4 / 8

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
2

                    

                    
                    
                    

                        
Atom Berat

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
Vidarabine (adenine arabinoside, Ara-A) is a purine nucleoside analog that is phosphorylated intracellularly to vidarabine triphosphate, which inhibits viral DNA polymerases and DNA primase, blocking viral DNA replication with selectivity for herpes viruses. It was used topically for herpes simplex keratitis and systemically for herpes encephalitis and neonatal herpes, but has largely been replaced by acyclovir due to the latter's improved safety and efficacy profile. Its antiviral mechanism targeting viral DNA polymerase established the template for subsequent nucleoside analog antivirals.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Vidarabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1090.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 21704.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.