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Zanamivir

CHEMBL222813 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
332.3 g/mol
LogP
-3.2
Phase
4

Zanamivir is a neuraminidase inhibitor that competitively blocks the influenza virus neuraminidase enzyme, preventing cleavage of sialic acid from host cell surface glycoproteins and inhibiting viral release, spread, and penetration of respiratory mucus. It is inhaled via the Diskhaler device for treatment and prevention of influenza A and B infections. Its topical inhalation route limits systemic bioavailability while delivering high drug concentrations to the respiratory tract.

Berat Molekul

332,3100 g/mol

LogP

-3,20

TPSA

201,00 Ų

Lipinski RO5

Lulus

Area Terapeutik

Respiratory Disease Asthma Chronic Obstructive Pulmonary Disease

Mekanisme Kerja

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Struktur 2D

SVG PNG

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SMILES

                    
CC(=O)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)OC(C(=O)O)=C[C@@H]1NC(=N)N

                

                

                
                

                    
InChI

                    
InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H20N4O7

                    

                    
                    

                        
HBD / HBA

                        
7 / 8

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
6

                    

                    
                    
                    

                        
Atom Berat

                        
23

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
Zanamivir is a neuraminidase inhibitor that competitively blocks the influenza virus neuraminidase enzyme, preventing cleavage of sialic acid from host cell surface glycoproteins and inhibiting viral release, spread, and penetration of respiratory mucus. It is inhaled via the Diskhaler device for treatment and prevention of influenza A and B infections. Its topical inhalation route limits systemic bioavailability while delivering high drug concentrations to the respiratory tract.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Zanamivir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL222813.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60855.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.