Deskripsi

Combining aspirin with escitalopram increases the risk of GI bleeding through additive impairment of hemostasis.

Mekanisme

Escitalopram depletes platelet serotonin via SERT blockade, reducing aggregation; aspirin inhibits COX-1–mediated thromboxane A2. Together they impair hemostasis through complementary mechanisms.

Signifikansi Klinis

Population studies show a 2- to 3-fold increase in upper GI hemorrhage with combined SSRI + aspirin vs. aspirin alone.

Penatalaksanaan

Co-prescribe a PPI when combining antidepressants with antiplatelet aspirin; counsel patients on GI bleeding warning signs.

Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.