Major
Probable
Deskripsi
Bupropion combined with tramadol increases the risk of both serotonin syndrome and seizures, representing a serious dual-hazard drug combination.
Mekanisme
Bupropion inhibits dopamine and norepinephrine reuptake and is a CYP2D6 inhibitor that elevates tramadol's serotonergic M1 metabolite; the combination raises CNS serotonin and lowers the seizure threshold.
Signifikansi Klinis
Both serotonin syndrome and seizure events have been documented in case reports with this combination.
Penatalaksanaan
Avoid concurrent use; if necessary, use the lowest effective tramadol dose and monitor for neurological symptoms closely.