Minor
Suspected
Deskripsi
Valsartan may slightly increase digoxin plasma levels by reducing its renal clearance; the interaction is generally modest.
Mekanisme
Angiotensin II promotes renal tubular secretion of digoxin; ARB-mediated angiotensin II blockade may reduce this secretion, marginally raising digoxin levels.
Signifikansi Klinis
Small increase in digoxin exposure; rarely clinically significant unless patient is already at the upper end of the therapeutic range.
Penatalaksanaan
Monitor digoxin levels when initiating valsartan in digitalized patients; adjust dose if levels exceed 1.2 ng/mL.