Major
Probable
Deskripsi
Both escitalopram and hydroxychloroquine prolong the QT interval; their concurrent use markedly increases the risk of potentially fatal arrhythmias.
Mekanisme
Both agents block hERG channels in a dose-dependent manner, producing additive prolongation of the QTc interval.
Signifikansi Klinis
FDA safety communications highlight QT prolongation risk for both drugs; their combination is considered high risk in patients with risk factors.
Penatalaksanaan
Avoid combination or use with extreme caution; obtain baseline ECG, monitor QTc throughout therapy, and correct electrolytes.