Deskripsi

Fluconazole inhibits CYP2C19 and CYP3A4, increasing sertraline plasma concentrations, which may enhance both therapeutic and adverse effects including QT prolongation.

Mekanisme

Fluconazole reduces sertraline clearance via CYP2C19 and CYP3A4 inhibition; higher sertraline levels increase serotonergic tone and may modestly prolong QTc.

Signifikansi Klinis

Sertraline AUC is significantly increased with fluconazole co-administration; clinical monitoring for adverse effects is warranted.

Penatalaksanaan

Monitor for sertraline side effects; consider sertraline dose reduction during fluconazole courses; obtain ECG if prolonged co-administration.

Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.