Moderate
Established
Deskripsi
Naproxen reduces the diuretic response to furosemide by inhibiting prostaglandin synthesis, potentially causing fluid retention and worsening edema or heart failure.
Mekanisme
Renal prostaglandins mediate part of furosemide's natriuretic action; naproxen-mediated prostaglandin inhibition blunts this response and promotes sodium reabsorption.
Signifikansi Klinis
Clinically relevant in patients with heart failure, nephrotic syndrome, or hepatic cirrhosis where diuretic response is already marginally adequate.
Penatalaksanaan
Avoid NSAIDs in patients dependent on furosemide for volume control; if necessary, monitor weight, BP, renal function, and electrolytes closely.