Moderate
Probable
Deskripsi
Sertraline combined with trazodone may increase the risk of serotonin syndrome due to additive serotonergic effects.
Mekanisme
Sertraline inhibits SERT; trazodone inhibits serotonin reuptake and is a 5-HT2 receptor antagonist, producing combined serotonergic stimulation.
Signifikansi Klinis
Case reports of serotonin syndrome exist; the combination is sometimes used for treatment-resistant depression with insomnia under close monitoring.
Penatalaksanaan
Use at the lowest effective doses; monitor for signs of serotonin toxicity including agitation, tremor, and hyperthermia.