Deskripsi

Simvastatin modestly potentiates warfarin anticoagulation, leading to small but potentially clinically relevant INR increases.

Mekanisme

Simvastatin may inhibit CYP2C9-mediated S-warfarin metabolism; the precise mechanism is not fully elucidated but has been observed across multiple statins.

Signifikansi Klinis

INR increases of ~10–20% have been observed; dose-dependent effect—higher simvastatin doses carry greater risk.

Penatalaksanaan

Monitor INR when starting, stopping, or changing the simvastatin dose; adjust warfarin if INR moves outside target range.

Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.