Alendronic Acid
A bisphosphonate drug that attaches to bone mineral and blocks the activity of osteoclasts, the cells responsible for breaking down bone tissue, thereby maintaining or increasing bone density. It is prescribed for osteoporosis, Paget's disease, and bone complications from certain cancers, reducing fracture risk with weekly or monthly dosing.
分子量
249.1000 g/mol
LogP
-6.50
TPSA
161.00 Ų
リピンスキーの五則
適合
治療領域
作用機序
Binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption by disrupting the mevalonate pathway within osteoclasts. This reduces bone turnover and increases bone mineral density.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption by disrupting the mevalonate pathway within osteoclasts. This reduces bone turnover and increases bone mineral density.
2D構造
Cite this structure
Embed this structure
SMILES
NCCCC(O)(P(=O)(O)O)P(=O)(O)O
InChI
InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12)
Molecular Formula
C4H13NO7P2
HBD / HBA
6 / 8
回転可能結合数
5
重原子数
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A bisphosphonate drug that attaches to bone mineral and blocks the activity of osteoclasts, the cells responsible for breaking down bone tissue, thereby maintaining or increasing bone density. It is prescribed for osteoporosis, Paget's disease, and bone complications from certain cancers, reducing fracture risk with weekly or monthly dosing.
Binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption by disrupting the mevalonate pathway within osteoclasts. This reduces bone turnover and increases bone mineral density.
Yes, Alendronic Acid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL870. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2088. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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