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Aliskiren

CHEMBL1639 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
551.8 g/mol
LogP
3.5
Phase
4

A direct renin inhibitor that works at the very beginning of the renin-angiotensin-aldosterone system to reduce blood pressure, blocking the enzyme renin from initiating the cascade that leads to blood vessel constriction and sodium retention. It lowers blood pressure effectively and has been studied for its kidney-protective effects in patients with diabetes and hypertension.

分子量

551.8000 g/mol

LogP

3.50

TPSA

146.00 Ų

リピンスキーの五則

適合

治療領域

Cardiovascular Disease Chronic Kidney Disease Obesity Type 2 Diabetes Hypertension Heart Failure Atrial Fibrillation

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@H](C(=O)NCC(C)(C)C(N)=O)C(C)C)C(C)C)ccc1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C30H53N3O6

                    

                    
                    

                        
HBD / HBA

                        
4 / 7

                    

                    
                    

                        
回転可能結合数

                        
19

                    

                    
                    
                    

                        
重原子数

                        
39

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
A direct renin inhibitor that works at the very beginning of the renin-angiotensin-aldosterone system to reduce blood pressure, blocking the enzyme renin from initiating the cascade that leads to blood vessel constriction and sodium retention. It lowers blood pressure effectively and has been studied for its kidney-protective effects in patients with diabetes and hypertension.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Aliskiren is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1639.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5493444.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.