Amifampridine Phosphate
The phosphate salt form of amifampridine, used to improve muscle strength in patients with Lambert-Eaton myasthenic syndrome by blocking voltage-gated potassium channels and increasing acetylcholine release. This stabilized formulation provides predictable dosing and is the approved form for treating this rare neuromuscular condition.
分子量
207.1200 g/mol
TPSA
143.00 Ų
作用機序
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
2D構造
Cite this structure
Embed this structure
SMILES
Nc1ccncc1N.O=P(O)(O)O
InChI
InChI=1S/C5H7N3.H3O4P/c6-4-1-2-8-3-5(4)7;1-5(2,3)4/h1-3H,7H2,(H2,6,8);(H3,1,2,3,4)
Molecular Formula
C5H10N3O4P
HBD / HBA
5 / 7
回転可能結合数
0
重原子数
13
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
The phosphate salt form of amifampridine, used to improve muscle strength in patients with Lambert-Eaton myasthenic syndrome by blocking voltage-gated potassium channels and increasing acetylcholine release. This stabilized formulation provides predictable dosing and is the approved form for treating this rare neuromuscular condition.
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Yes, Amifampridine Phosphate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3301611. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9920716. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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