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Amifampridine

CHEMBL354077 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
109.1 g/mol
LogP
-0.5
Phase
4

A potassium channel blocker that prolongs nerve action potentials, thereby increasing acetylcholine release at neuromuscular junctions, used to treat Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune neuromuscular disorder. By compensating for the impaired nerve-to-muscle signaling caused by autoantibodies in LEMS, it improves muscle strength.

分子量

109.1300 g/mol

LogP

-0.50

TPSA

64.90 Ų

リピンスキーの五則

適合

治療領域

Multiple Sclerosis

作用機序

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Nc1ccncc1N

                

                

                
                

                    
InChI

                    
InChI=1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)

                

                

                

                    
                    

                        
Molecular Formula

                        
C5H7N3

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
回転可能結合数

                        
0

                    

                    
                    
                    

                        
重原子数

                        
8

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
A potassium channel blocker that prolongs nerve action potentials, thereby increasing acetylcholine release at neuromuscular junctions, used to treat Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune neuromuscular disorder. By compensating for the impaired nerve-to-muscle signaling caused by autoantibodies in LEMS, it improves muscle strength.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Amifampridine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL354077.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5918.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.