Amitriptyline
A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.
分子量
277.4000 g/mol
LogP
5.00
TPSA
3.20 Ų
リピンスキーの五則
適合
治療領域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
CN(C)CCC=C1c2ccccc2CCc2ccccc21
InChI
InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
Molecular Formula
C20H23N
HBD / HBA
- / 1
回転可能結合数
3
重原子数
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.
Yes, Amitriptyline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL629. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2160. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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