Bendamustine
A chemotherapy agent with dual alkylating and antimetabolite properties that cross-links and breaks DNA strands in cancer cells, triggering cell death. It is used in lymphomas, chronic lymphocytic leukemia, and multiple myeloma.
分子量
358.3000 g/mol
LogP
2.90
TPSA
58.40 Ų
リピンスキーの五則
適合
治療領域
作用機序
Acts as an antimetabolite by incorporating into DNA or RNA or by inhibiting enzymes essential for nucleic acid synthesis. This disrupts DNA replication and causes cell death in rapidly dividing cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Acts as an antimetabolite by incorporating into DNA or RNA or by inhibiting enzymes essential for nucleic acid synthesis. This disrupts DNA replication and causes cell death in rapidly dividing …
2D構造
Cite this structure
Embed this structure
SMILES
Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21
InChI
InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)
Molecular Formula
C16H21Cl2N3O2
HBD / HBA
1 / 4
回転可能結合数
9
重原子数
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A chemotherapy agent with dual alkylating and antimetabolite properties that cross-links and breaks DNA strands in cancer cells, triggering cell death. It is used in lymphomas, chronic lymphocytic leukemia, and multiple myeloma.
Acts as an antimetabolite by incorporating into DNA or RNA or by inhibiting enzymes essential for nucleic acid synthesis. This disrupts DNA replication and causes cell death in rapidly dividing cells.
Yes, Bendamustine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL487253. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 65628. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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