Benzonatate
A non-narcotic cough suppressant that works by numbing the stretch receptors in the airways and lungs, reducing the urge to cough. It is used to relieve uncomfortable, nonproductive coughing. Unlike opioid cough medicines, it does not affect the brain's cough center.
分子量
603.7000 g/mol
LogP
2.40
TPSA
121.00 Ų
リピンスキーの五則
不適合
作用機序
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
2D構造
Cite this structure
Embed this structure
SMILES
CCCCNc1ccc(C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)cc1
InChI
InChI=1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3
Molecular Formula
C30H53NO11
HBD / HBA
1 / 12
回転可能結合数
33
重原子数
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A non-narcotic cough suppressant that works by numbing the stretch receptors in the airways and lungs, reducing the urge to cough. It is used to relieve uncomfortable, nonproductive coughing. Unlike opioid cough medicines, it does not affect the brain's cough center.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Benzonatate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1374379. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 7699. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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