Butorphanol Tartrate
The tartrate salt of butorphanol, a mixed opioid analgesic with agonist activity at kappa receptors and antagonist-to-partial-agonist activity at mu receptors. The nasal spray formulation offers a convenient non-injectable route for pain and migraine management. Psychotomimetic side effects such as dysphoria and hallucinations can occur.
分子量
477.5000 g/mol
TPSA
159.00 Ų
治療領域
作用機序
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
2D構造
Cite this structure
Embed this structure
SMILES
O=C(O)C(O)C(O)C(=O)O.Oc1ccc2c(c1)[C@@]13CCCC[C@@]1(O)[C@@H](C2)N(CC1CCC1)CC3
InChI
InChI=1S/C21H29NO2.C4H6O6/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15;5-1(3(7)8)2(6)4(9)10/h6-7,13,15,19,23-24H,1-5,8-12,14H2;1-2,5-6H,(H,7,8)(H,9,10)/t19-,20+,21-;/m1./s1
Molecular Formula
C25H35NO8
HBD / HBA
6 / 9
回転可能結合数
5
重原子数
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
The tartrate salt of butorphanol, a mixed opioid analgesic with agonist activity at kappa receptors and antagonist-to-partial-agonist activity at mu receptors. The nasal spray formulation offers a convenient non-injectable route for pain and migraine management. Psychotomimetic side effects such as dysphoria and hallucinations can occur.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Butorphanol Tartrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL299400. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5464090. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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