Daridorexant Hydrochloride
The hydrochloride salt form of daridorexant, an orexin receptor antagonist approved for chronic insomnia disorder. It selectively blocks orexin receptors to reduce wakefulness without causing the dependency associated with benzodiazepines.
分子量
487.4000 g/mol
TPSA
88.90 Ų
作用機序
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, …
2D構造
Cite this structure
Embed this structure
SMILES
COc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@]2(C)c2nc3c(C)c(Cl)ccc3[nH]2)c1.Cl
InChI
InChI=1S/C23H23ClN6O2.ClH/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30;/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28);1H/t23-;/m0./s1
Molecular Formula
C23H24Cl2N6O2
HBD / HBA
2 / 5
回転可能結合数
4
重原子数
33
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
The hydrochloride salt form of daridorexant, an orexin receptor antagonist approved for chronic insomnia disorder. It selectively blocks orexin receptors to reduce wakefulness without causing the dependency associated with benzodiazepines.
Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors by binding to an allosteric site and increasing the frequency of chloride ion channel opening. This produces anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Yes, Daridorexant Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4650216. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 91809208. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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