Dexlansoprazole
A modified-release proton pump inhibitor and the R-enantiomer of lansoprazole that uses a dual delayed-release formulation to provide two separate drug-release phases, maintaining acid suppression for longer periods. It is used for gastroesophageal reflux disease and erosive esophagitis.
分子量
369.4000 g/mol
LogP
2.80
TPSA
87.10 Ų
リピンスキーの五則
適合
治療領域
作用機序
Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid suppression.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid …
2D構造
Cite this structure
Embed this structure
SMILES
Cc1c(OCC(F)(F)F)ccnc1C[S@@+]([O-])c1nc2ccccc2[nH]1
InChI
InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)/t25-/m1/s1
Molecular Formula
C16H14F3N3O2S
HBD / HBA
1 / 8
回転可能結合数
5
重原子数
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A modified-release proton pump inhibitor and the R-enantiomer of lansoprazole that uses a dual delayed-release formulation to provide two separate drug-release phases, maintaining acid suppression for longer periods. It is used for gastroesophageal reflux disease and erosive esophagitis.
Irreversibly inhibits the hydrogen-potassium ATPase (proton pump) on the apical surface of gastric parietal cells. This blocks the final common pathway of gastric acid secretion, producing profound and sustained acid suppression.
Yes, Dexlansoprazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201863. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9578005. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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