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Glasdegib

CHEMBL2043437 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
374.4 g/mol
LogP
2.4
Phase
4

A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.

分子量

374.4000 g/mol

LogP

2.40

TPSA

96.80 Ų

リピンスキーの五則

適合

治療領域

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CN1CC[C@@H](NC(=O)Nc2ccc(C#N)cc2)C[C@@H]1c1nc2ccccc2[nH]1

                

                

                
                

                    
InChI

                    
InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C21H22N6O

                    

                    
                    

                        
HBD / HBA

                        
3 / 4

                    

                    
                    

                        
回転可能結合数

                        
3

                    

                    
                    
                    

                        
重原子数

                        
28

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
A hedgehog pathway inhibitor that blocks Smoothened, a protein involved in the abnormal cell signaling pathway that drives certain leukemias. It is approved in combination with low-dose cytarabine for treating newly diagnosed acute myeloid leukemia in adults who are not eligible for intensive chemotherapy. Blocking this pathway suppresses leukemia stem cell self-renewal.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Glasdegib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL2043437.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 25166913.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.