Iobenguane
This compound is a guanethidine analogue that, when labeled with radioactive iodine, is used for imaging or treating tumors of the adrenal medulla (pheochromocytoma) and related neuroendocrine tumors. It accumulates in these tumors due to active uptake by norepinephrine transporters. The radioactive form allows both diagnostic scanning and targeted radiation therapy.
分子量
275.0900 g/mol
LogP
1.00
TPSA
64.40 Ų
リピンスキーの五則
適合
治療領域
作用機序
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
2D構造
Cite this structure
Embed this structure
SMILES
N=C(N)NCc1cccc(I)c1
InChI
InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
Molecular Formula
C8H10IN3
HBD / HBA
2 / 1
回転可能結合数
2
重原子数
12
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
This compound is a guanethidine analogue that, when labeled with radioactive iodine, is used for imaging or treating tumors of the adrenal medulla (pheochromocytoma) and related neuroendocrine tumors. It accumulates in these tumors due to active uptake by norepinephrine transporters. The radioactive form allows both diagnostic scanning and targeted radiation therapy.
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Yes, Iobenguane is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL818. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60860. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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