Methylnaltrexone
A peripherally acting opioid antagonist used to relieve opioid-induced constipation in patients with chronic non-cancer pain or advanced illness. It blocks opioid receptors in the gut without affecting pain control.
分子量
356.4000 g/mol
LogP
1.60
TPSA
66.80 Ų
リピンスキーの五則
適合
治療領域
作用機序
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission …
2D構造
Cite this structure
Embed this structure
SMILES
C[N+]1(CC2CC2)CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
InChI
InChI=1S/C21H25NO4/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13/h4-5,12,16,19,25H,2-3,6-11H2,1H3/p+1/t16-,19+,20+,21-,22?/m1/s1
Molecular Formula
C21H26NO4+
HBD / HBA
2 / 4
回転可能結合数
2
重原子数
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A peripherally acting opioid antagonist used to relieve opioid-induced constipation in patients with chronic non-cancer pain or advanced illness. It blocks opioid receptors in the gut without affecting pain control.
Binds to mu (μ), kappa (κ), and/or delta (δ) opioid receptors in the central and peripheral nervous system, mimicking endogenous endorphins. Activation of these G-protein-coupled receptors inhibits pain signal transmission and modulates the emotional response to pain.
Yes, Methylnaltrexone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1186579. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5361918. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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