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Netarsudil

CHEMBL4594250 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
453.5 g/mol
LogP
4.6
Phase
4

This eye drop is used to lower elevated pressure inside the eye in patients with open-angle glaucoma or ocular hypertension. It works through a novel mechanism by reducing fluid production in the eye and improving fluid drainage, helping to prevent vision loss.

分子量

453.5000 g/mol

LogP

4.60

TPSA

94.30 Ų

リピンスキーの五則

適合

治療領域

Glaucoma Hypertension

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1ccc(C(=O)OCc2ccc([C@@H](CN)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C28H27N3O3/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)/t26-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C28H27N3O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 5

                    

                    
                    

                        
回転可能結合数

                        
8

                    

                    
                    
                    

                        
重原子数

                        
34

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
This eye drop is used to lower elevated pressure inside the eye in patients with open-angle glaucoma or ocular hypertension. It works through a novel mechanism by reducing fluid production in the eye and improving fluid drainage, helping to prevent vision loss.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Netarsudil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4594250.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 66599893.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.