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Nirogacestat

CHEMBL1770916 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
489.6 g/mol
LogP
4.8
Phase
4

A gamma-secretase inhibitor that blocks Notch signaling and reduces desmoid tumor growth, approved to treat adults with progressing desmoid tumors. It works by inhibiting an enzyme that cleaves Notch receptor proteins needed for tumor cell proliferation.

分子量

489.6000 g/mol

LogP

4.80

TPSA

71.00 Ų

リピンスキーの五則

適合

治療領域

Ovarian Cancer Breast Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CNCC(C)(C)C)cn1

                

                

                
                

                    
InChI

                    
InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C27H41F2N5O

                    

                    
                    

                        
HBD / HBA

                        
3 / 6

                    

                    
                    

                        
回転可能結合数

                        
11

                    

                    
                    
                    

                        
重原子数

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
A gamma-secretase inhibitor that blocks Notch signaling and reduces desmoid tumor growth, approved to treat adults with progressing desmoid tumors. It works by inhibiting an enzyme that cleaves Notch receptor proteins needed for tumor cell proliferation.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Nirogacestat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1770916.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 46224413.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.