Omeprazole
Omeprazole is a proton pump inhibitor that shuts down stomach acid production at its source. It irreversibly blocks the H+/K+-ATPase, the enzyme that pumps acid into the stomach lumen, so a single dose can suppress secretion for far longer than its brief presence in the blood would suggest. This makes it effective for heartburn, acid reflux, and peptic ulcers. A small molecule (C17H19N3O3S) with a very short half-life of about half an hour to an hour, it nonetheless produces prolonged acid suppression because the enzyme must be newly synthesized before acid output recovers. Its action depends on activation within the acidic environment of the pump itself, targeting the tissue where it is needed. Omeprazole is an approved medicine widely used for acid-related digestive disorders.
A proton pump inhibitor blocking stomach acid production for heartburn, reflux, and ulcers.
分子量
345.4170 g/mol
LogP
2.20
TPSA
96.30 Ų
リピンスキーの五則
適合
治療領域
薬物分類
作用機序
Proton pump inhibitor that irreversibly blocks H+/K+-ATPase.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Proton pump inhibitor that irreversibly blocks H+/K+-ATPase.
2D構造
Cite this structure
Embed this structure
SMILES
COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1
InChI
InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
Molecular Formula
C17H19N3O3S
HBD / HBA
1 / 6
回転可能結合数
5
重原子数
24
Omeprazole may modestly increase warfarin plasma concentrations through weak CYP2C19 inhibition; the clinical effect is generally small but warrants awareness.
Omeprazole does not have a pharmacokinetic interaction with pregabalin since pregabalin is not CYP-metabolised; however, both can cause peripheral oedema through independent mechanisms, producing additive fluid retention.
Omeprazole inhibits CYP2C19 and weakly inhibits CYP3A4, leading to modest increases in tacrolimus exposure particularly in CYP2C19 poor metabolisers.
Omeprazole can modestly increase the rate of acetaminophen absorption by altering gastric pH, but the effect on overall bioavailability and therapeutic outcome is not clinically meaningful under most circumstances.
Omeprazole reduces the antiplatelet efficacy of clopidogrel by inhibiting its bioactivation via CYP2C19, potentially increasing thrombotic risk.
Carbamazepine reduces omeprazole plasma concentrations through CYP3A4 induction, potentially reducing the efficacy of acid suppression therapy.
Omeprazole raises gastric pH, which impairs the dissolution and absorption of levothyroxine, resulting in reduced thyroid hormone bioavailability and potential hypothyroid relapse.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
A proton pump inhibitor blocking stomach acid production for heartburn, reflux, and ulcers.
Proton pump inhibitor that irreversibly blocks H+/K+-ATPase.
Key pharmacokinetic parameters for Omeprazole: Half-life: 0.5-1 hour.
Yes, Omeprazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
Same Drug Class
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1503. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4594. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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