Quinacrine
Quinacrine is an acridine compound with antimalarial, antiprotozoal, and antineoplastic properties that intercalates into DNA, inhibits phospholipase A2, and blocks sodium and calcium channels, producing multiple cellular effects including inhibition of telomerase and induction of apoptosis in cancer cells. It was widely used for malaria prophylaxis during World War II and has been investigated for its anticancer activity in non-small cell lung cancer and other malignancies.
分子量
400.0000 g/mol
LogP
6.00
TPSA
37.40 Ų
リピンスキーの五則
適合
治療領域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
InChI
InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
Molecular Formula
C23H30ClN3O
HBD / HBA
1 / 4
回転可能結合数
9
重原子数
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Quinacrine is an acridine compound with antimalarial, antiprotozoal, and antineoplastic properties that intercalates into DNA, inhibits phospholipase A2, and blocks sodium and calcium channels, producing multiple cellular effects including inhibition of telomerase and induction of apoptosis in cancer cells. It was widely used for malaria prophylaxis during World War II and has been investigated for its anticancer activity in non-small cell lung cancer and other malignancies.
Yes, Quinacrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL7568. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 237. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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