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Quizartinib

CHEMBL576982 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
560.7 g/mol
LogP
5.6
Phase
4

Quizartinib is a highly selective FLT3 kinase inhibitor that potently blocks constitutively activating FLT3 internal tandem duplication (ITD) mutations driving aberrant proliferation and survival of leukemic blast cells. It is approved for the treatment of adults with FLT3-ITD-positive acute myeloid leukemia (AML) in combination with standard cytarabine and anthracycline induction chemotherapy and continuation therapy.

分子量

560.7000 g/mol

LogP

5.60

TPSA

134.00 Ų

リピンスキーの五則

不適合

治療領域

Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1

                

                

                
                

                    
InChI

                    
InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

                

                

                

                    
                    

                        
Molecular Formula

                        
C29H32N6O4S

                    

                    
                    

                        
HBD / HBA

                        
2 / 8

                    

                    
                    

                        
回転可能結合数

                        
8

                    

                    
                    
                    

                        
重原子数

                        
40

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Quizartinib is a highly selective FLT3 kinase inhibitor that potently blocks constitutively activating FLT3 internal tandem duplication (ITD) mutations driving aberrant proliferation and survival of leukemic blast cells. It is approved for the treatment of adults with FLT3-ITD-positive acute myeloid leukemia (AML) in combination with standard cytarabine and anthracycline induction chemotherapy and continuation therapy.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Quizartinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL576982.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 24889392.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.