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Revumenib

CHEMBL4650827 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
630.8 g/mol
LogP
4.3
Phase
4

Revumenib is a potent, selective menin inhibitor that disrupts the interaction between the menin protein and KMT2A (MLL1) fusion oncoproteins, restoring normal differentiation programs in leukemic cells by abrogating aberrant transcriptional activation of HOXA genes and MEIS1. It is approved for relapsed or refractory acute leukemia with KMT2A translocation and is under investigation in NPM1-mutant AML and other menin-dependent malignancies.

分子量

630.8000 g/mol

LogP

4.30

TPSA

116.00 Ų

リピンスキーの五則

適合

治療領域

Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCN(C(=O)c1cc(F)ccc1Oc1cncnc1N1CC2(CCN(C[C@H]3CC[C@H](NS(=O)(=O)CC)CC3)CC2)C1)C(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C32H47FN6O4S/c1-5-39(23(3)4)31(40)27-17-25(33)9-12-28(27)43-29-18-34-22-35-30(29)38-20-32(21-38)13-15-37(16-14-32)19-24-7-10-26(11-8-24)36-44(41,42)6-2/h9,12,17-18,22-24,26,36H,5-8,10-11,13-16,19-21H2,1-4H3/t24-,26-

                

                

                

                    
                    

                        
Molecular Formula

                        
C32H47FN6O4S

                    

                    
                    

                        
HBD / HBA

                        
1 / 10

                    

                    
                    

                        
回転可能結合数

                        
11

                    

                    
                    
                    

                        
重原子数

                        
44

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Revumenib is a potent, selective menin inhibitor that disrupts the interaction between the menin protein and KMT2A (MLL1) fusion oncoproteins, restoring normal differentiation programs in leukemic cells by abrogating aberrant transcriptional activation of HOXA genes and MEIS1. It is approved for relapsed or refractory acute leukemia with KMT2A translocation and is under investigation in NPM1-mutant AML and other menin-dependent malignancies.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Revumenib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL4650827.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 132212657.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.