Selinexor
Selinexor is a first-in-class selective inhibitor of nuclear export (SINE) compound that blocks exportin 1 (XPO1/CRM1), the major nuclear export protein, causing nuclear accumulation of tumor suppressor proteins and pro-apoptotic factors. It is approved for relapsed/refractory multiple myeloma and diffuse large B-cell lymphoma, and is under investigation for multiple other malignancies. By trapping p53, p21, and other tumor suppressors in the nucleus, selinexor restores their antiproliferative and pro-apoptotic functions.
分子量
443.3000 g/mol
LogP
3.00
TPSA
97.60 Ų
リピンスキーの五則
適合
治療領域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
2D構造
Cite this structure
Embed this structure
SMILES
O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1
InChI
InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-
Molecular Formula
C17H11F6N7O
HBD / HBA
2 / 12
回転可能結合数
5
重原子数
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
よくある質問
Selinexor is a first-in-class selective inhibitor of nuclear export (SINE) compound that blocks exportin 1 (XPO1/CRM1), the major nuclear export protein, causing nuclear accumulation of tumor suppressor proteins and pro-apoptotic factors. It is approved for relapsed/refractory multiple myeloma and diffuse large B-cell lymphoma, and is under investigation for multiple other malignancies. By trapping p53, p21, and other tumor suppressors in the nucleus, selinexor restores their antiproliferative and pro-apoptotic functions.
Yes, Selinexor is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3545185. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71481097. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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