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Suxamethonium

CHEMBL703 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
290.4 g/mol
LogP
0.6
Phase
4

Suxamethonium (succinylcholine) is a depolarizing neuromuscular blocking agent that mimics acetylcholine at the neuromuscular junction nicotinic receptors, causing initial fasciculations followed by sustained depolarization and flaccid skeletal muscle paralysis used for rapid sequence induction and tracheal intubation. Its rapid onset of action (30-60 seconds) and short duration (10-15 minutes due to plasma cholinesterase hydrolysis) make it uniquely suited for emergency airway management. It carries risks of hyperkalemic cardiac arrest in patients with denervation injuries, burns, or prolonged immobility.

分子量

290.4000 g/mol

LogP

0.60

TPSA

52.60 Ų

リピンスキーの五則

適合

治療領域

Infectious Disease Glaucoma Pain Management Rheumatoid Arthritis Schizophrenia Bipolar Disorder Stroke Obesity Major Depressive Disorder Breast Cancer Chronic Pain Colorectal Cancer

作用機序

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

                

                

                
                

                    
InChI

                    
InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H30N2O4+2

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
回転可能結合数

                        
11

                    

                    
                    
                    

                        
重原子数

                        
20

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Suxamethonium (succinylcholine) is a depolarizing neuromuscular blocking agent that mimics acetylcholine at the neuromuscular junction nicotinic receptors, causing initial fasciculations followed by sustained depolarization and flaccid skeletal muscle paralysis used for rapid sequence induction and tracheal intubation. Its rapid onset of action (30-60 seconds) and short duration (10-15 minutes due to plasma cholinesterase hydrolysis) make it uniquely suited for emergency airway management. It carries risks of hyperkalemic cardiac arrest in patients with denervation injuries, burns, or prolonged immobility.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Suxamethonium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL703.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5314.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.