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Tafluprost

CHEMBL1963683 Phase 4 承認済み Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
452.5 g/mol
LogP
4.5
Phase
4

Tafluprost is a fluorinated prostanoid analog of latanoprost, a selective prostaglandin FP receptor agonist used as a preservative-free ophthalmic solution for reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension. By increasing uveoscleral outflow of aqueous humor through FP receptor activation on ciliary smooth muscle, it reduces IOP without affecting aqueous humor production. The preservative-free formulation is particularly beneficial for patients with ocular surface disease.

分子量

452.5000 g/mol

LogP

4.50

TPSA

76.00 Ų

リピンスキーの五則

適合

治療領域

Glaucoma Hypertension

作用機序

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

機序

Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

2D構造

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(C)OC(=O)CCC/C=C\C[C@@H]1[C@@H](/C=C/C(F)(F)COc2ccccc2)[C@H](O)C[C@@H]1O

                

                

                
                

                    
InChI

                    
InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H34F2O5

                    

                    
                    

                        
HBD / HBA

                        
2 / 7

                    

                    
                    

                        
回転可能結合数

                        
13

                    

                    
                    
                    

                        
重原子数

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
よくある質問

                

                    
                    

                        
                        

                            
Tafluprost is a fluorinated prostanoid analog of latanoprost, a selective prostaglandin FP receptor agonist used as a preservative-free ophthalmic solution for reduction of elevated intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension. By increasing uveoscleral outflow of aqueous humor through FP receptor activation on ciliary smooth muscle, it reduces IOP without affecting aqueous humor production. The preservative-free formulation is particularly beneficial for patients with ocular surface disease.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tafluprost is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1963683.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9868491.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医学的免責事項

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.